CDK12 anticorps (AA 50-130)

N° du produit ABIN7227782

L’anticorps anti-CDK12 Polyclonal Lapin est utilisé pour la détection de CDK12 dans des échantillons de Humain et Rat. Il a été validé pour ELISA et WB.

Aperçu rapide pour CDK12 anticorps (AA 50-130) (ABIN7227782)

Antigène: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK12 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-CDK12 anticorps

Épitope: AA 50-130

Fonction: Rabbit Anti-CDK12 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of CDK12 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human CDK12 protein at AA range: 50-130

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur CDK12

Antigène: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Autre désignation: CDK12

Sujet: Cyclin-dependent kinase 12, Cdc2-related kinase, arginine/serine-rich, CrkRS, Cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, Cell division protein kinase 12, hCDK12CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Among its related pathways are DNA Damage and Formation of HIV elongation complex in the absence of HIV Tat. Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates Ser-5 in CTD repeats that are already phosphorylated at Ser-7, but can also phosphorylate Ser-2. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Poids moléculaire: 163kD

ID gène: 51755

UniProt: Q9NYV4