CCAR1 anticorps (AA 840-920)

N° du produit ABIN7227630

Cet anticorps Lapin Polyclonal détecte spécifiquement CCAR1 dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour CCAR1 anticorps (AA 840-920) (ABIN7227630)

Antigène: CCAR1 (Cell Division Cycle and Apoptosis Regulator 1 (CCAR1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCAR1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CCAR1 anticorps

Épitope: AA 840-920

Fonction: Rabbit Anti-CCAR1 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of CCAR1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human CCAR1 protein at AA range: 840-920

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur CCAR1

Antigène: CCAR1 (Cell Division Cycle and Apoptosis Regulator 1 (CCAR1))

Autre désignation: CCAR1

Sujet: Cell division cycle and apoptosis regulator protein 1, Cell cycle and apoptosis regulatory protein 1, CARP-1, Death inducer with SAP domainAssociates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells.

Poids moléculaire: 126kD

ID gène: 55749

UniProt: Q8IX12