CEP57 anticorps (AA 210-290)

N° du produit ABIN7226070

Cet anticorps anti-CEP57 Polyclonal Lapin (ABIN7226070) détecte spécifiquement CEP57 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CEP57 anticorps (AA 210-290) (ABIN7226070)

Antigène: CEP57 (Centrosomal Protein 57kDa (CEP57))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CEP57 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CEP57 anticorps

Épitope: AA 210-290

Fonction: Rabbit Anti-CEP57 Polyclonal Antibody

Specificité: CEP57 Polyclonal Antibody detects endogenous levels of CEP57 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the Internal region of human CEP57 at AA range: 210-290

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur CEP57

Antigène: CEP57 (Centrosomal Protein 57kDa (CEP57))

Autre désignation: CEP57

Sujet: CEP57, KIAA0092, TSP57, Centrosomal protein of 57 kDa, Cep57, FGF2-interacting protein, Testis-specific protein 57, TranslokinCEP57 (centrosomal protein 57) encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in CEP57 cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Poids moléculaire: 50kD

ID gène: 9702

UniProt: Q86XR8

Pathways: M Phase, Maintenance of Protein Location, Protein targeting to Nucleus, Growth Factor Binding