Claudin 6 anticorps (pTyr219)

N° du produit ABIN7225802

Cet anticorps Lapin Polyclonal détecte spécifiquement Claudin 6 dans ELISA, WB, IHC et IF. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour Claudin 6 anticorps (pTyr219) (ABIN7225802)

Antigène: Claudin 6 (CLDN6)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claudin 6 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Claudin 6 anticorps

Épitope: pTyr219

Fonction: Rabbit Anti-Claudin-6 (phospho Tyr219) Polyclonal Antibody

Specificité: Phospho-Claudin-6 (Y219) Polyclonal Antibody detects endogenous levels of Claudin-6 protein only when phosphorylated at Y219.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Claudin-6 Phospho-Tyr219

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:5000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Claudin 6

Antigène: Claudin 6 (CLDN6)

Autre désignation: Claudin-6

Sujet: CLDN6, Claudin-6, SkullinTight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. CLDN6 (claudin 6) encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. CLDN6 methylation may be involved in esophageal tumorigenesis. CLDN6 is adjacent to another family member CLDN9 on chromosome 16.

Poids moléculaire: 23kD

ID gène: 9074

UniProt: P56747

Pathways: Hepatitis C