CSTB anticorps (AA 20-60)

N° du produit ABIN7228134

L’anticorps anti-CSTB Polyclonal Lapin est utilisé pour la détection de CSTB dans des échantillons de Humain, Rat et Souris. Il a été validé pour IHC, ELISA et IF.

Aperçu rapide pour CSTB anticorps (AA 20-60) (ABIN7228134)

Antigène: CSTB (Cystatin B (Stefin B) (CSTB))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSTB est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-CSTB anticorps

Épitope: AA 20-60

Fonction: Rabbit Anti-Cystatin B Polyclonal Antibody

Specificité: The antibody detects endogenous levels of Cystatin B

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human Cystatin B protein at AA range: 20-60

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur CSTB

Antigène: CSTB (Cystatin B (Stefin B) (CSTB))

Autre désignation: Cystatin B

Sujet: Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-BThe cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies.

ID gène: 1476

UniProt: P04080

Pathways: Response to Water Deprivation