DHRS2 anticorps (AA 80-160)

N° du produit ABIN7214562

Cet anticorps anti-DHRS2 Polyclonal Lapin (ABIN7214562) détecte spécifiquement DHRS2 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour DHRS2 anticorps (AA 80-160) (ABIN7214562)

Antigène: DHRS2 (Dehydrogenase/reductase (SDR Family) Member 2 (DHRS2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DHRS2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-DHRS2 anticorps

Épitope: AA 80-160

Fonction: Rabbit Anti-DHRS2 Polyclonal Antibody

Specificité: DHRS2 Polyclonal Antibody detects endogenous levels of DHRS2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the Internal region of human DHRS2 at AA range: 80-160

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur DHRS2

Antigène: DHRS2 (Dehydrogenase/reductase (SDR Family) Member 2 (DHRS2))

Autre désignation: DHRS2

Sujet: DHRS2, Dehydrogenase/reductase SDR family member 2, Dicarbonyl reductase HEP27, Protein DDHRS2 (dehydrogenase/reductase (SDR family) member 2), also known as SDR25C1 or HEP27, is a 258 amino acid protein that localizes to the nucleus and belongs to the short-chain dehydrogenase/reductase (SDR) family. Functioning as an NADPH-dependent dicarbonyl reductase, DHRS2 is thought to inhibit cell replication by either converting cortisone in cortisol, or by catalyzing the oxidation of androgen and estrogen. The gene encoding DHRS2 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5 % of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.

Poids moléculaire: 27kD

ID gène: 10202

UniProt: Q13268

Pathways: C21-Steroid Hormone Metabolic Process