DNA Polymerase zeta (AA 200-280) anticorps

N° du produit ABIN7224004

L’anticorps anti-DNA Polymerase zeta Polyclonal Lapin est utilisé pour la détection de DNA Polymerase zeta dans des échantillons de Humain et Souris. Il a été validé pour IHC, ELISA et IF.

Aperçu rapide pour DNA Polymerase zeta (AA 200-280) anticorps (ABIN7224004)

Antigène: DNA Polymerase zeta

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit

Épitope: AA 200-280

Fonction: Rabbit Anti-DNA pol ζ Polyclonal Antibody

Specificité: DNA pol ζ Polyclonal Antibody detects endogenous levels of DNA pol ζ protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the N-terminal region of human DNA pol zeta at AA range: 200-280

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détail du antigène

Antigène: DNA Polymerase zeta

Autre désignation: DNA pol zeta

Sujet: REV3L, POLZ, REV3, DNA polymerase zeta catalytic subunit, Protein reversionless 3-like, REV3-like, hREV3DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol α, β, δ, and e are involved in DNA replication and repair. DNA pol δ and DNA pol e are multisubunit enzymes, with DNA pol δ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50. The nuclear-encoded DNA pol γ is the only DNA polymerase required for the replication of the mitochondrial DNA. DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis. DNA pol is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks.

ID gène: 5980

UniProt: O60673