Doublecortin anticorps (pSer376)

N° du produit ABIN7219988

Cet anticorps anti-Doublecortin Polyclonal Lapin (ABIN7219988) détecte spécifiquement Doublecortin dans ELISA, IHC et IF. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat et Porc.

Aperçu rapide pour Doublecortin anticorps (pSer376) (ABIN7219988)

Antigène: Doublecortin (DCX)

Reactivité: Humain, Souris, Rat, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Doublecortin est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Doublecortin anticorps

Épitope: pSer376

Fonction: Rabbit Anti-Doublecortin (phospho Ser376) Polyclonal Antibody

Specificité: Phospho-Doublecortin (S376) Polyclonal Antibody detects endogenous levels of Doublecortin protein only when phosphorylated at S376.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Doublecortin Phospho-Ser376

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:5000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Doublecortin

Antigène: Doublecortin (DCX)

Autre désignation: Doublecortin

Sujet: DCX, DBCN, LISX, Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-XDCX encodes a member of the doublecortin family. Neuronal migration protein doublecortin encoded by DCX is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

ID gène: 1641

UniProt: O43602