Coagulation Factor X anticorps (Cleaved-Ala41)

N° du produit ABIN7212514

Cet anticorps Lapin Polyclonal détecte spécifiquement Coagulation Factor X dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Coagulation Factor X anticorps (Cleaved-Ala41) (ABIN7212514)

Antigène: Coagulation Factor X (F10)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Coagulation Factor X est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Coagulation Factor X anticorps

Épitope: AA 370-450, Cleaved-Ala41

Fonction: Rabbit Anti-Cleaved-Factor X/ Factor X LC (A41) Polyclonal Antibody

Specificité: Cleaved-Factor X/ Factor X LC (A41) Polyclonal Antibody detects endogenous levels of fragment of activated Factor X/ Factor X LC protein resulting from cleavage adjacent to A41.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the N-terminal region of human Factor X/ Factor X LC at AA range: 370-450

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Coagulation Factor X

Antigène: Coagulation Factor X (F10)

Autre désignation: Factor X/ Factor X LC

Sujet: F10, Coagulation factor X, Stuart factor, Stuart-Prower factorF10 encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds, the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Poids moléculaire: 50kD

ID gène: 2159

UniProt: P00742