GRID2 anticorps (AA 800-880)

N° du produit ABIN7221306

L’anticorps anti-GRID2 Polyclonal Lapin est utilisé pour la détection de GRID2 dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, IF et ELISA.

Aperçu rapide pour GRID2 anticorps (AA 800-880) (ABIN7221306)

Antigène: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRID2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA

Détail du produit anti-GRID2 anticorps

Épitope: AA 800-880

Fonction: Rabbit Anti-GluR-δ2 Polyclonal Antibody

Specificité: GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the C-terminal region of human GluR-delta2 at AA range: 800-880

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur GRID2

Antigène: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Autre désignation: GluR-delta2

Sujet: GRID2, GLURD2, Glutamate receptor delta-2 subunit, GluR delta-2 subunitThe glutamate ionotropic receptor delta type subunit 2 encoded by GRID2 is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

Poids moléculaire: 113kD

ID gène: 2895

UniProt: O43424

Pathways: Synaptic Membrane