HUS1 anticorps (AA 160-240)

N° du produit ABIN7228986

Cet anticorps anti-HUS1 Polyclonal Lapin (ABIN7228986) détecte spécifiquement HUS1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour HUS1 anticorps (AA 160-240) (ABIN7228986)

Antigène: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HUS1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-HUS1 anticorps

Épitope: AA 160-240

Fonction: Rabbit Anti-HUS1 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of HUS1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human HUS1 protein at AA range: 160-240

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur HUS1

Antigène: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Autre désignation: HUS1

Sujet: Checkpoint protein HUS1, hHUS1The protein encoded by HUS1 is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 30kD

ID gène: 3364

UniProt: O60921