JAK2/3 anticorps (pTyr939, pTyr966)

N° du produit ABIN7229208

Cet anticorps anti-JAK2/3 Polyclonal Lapin (ABIN7229208) détecte spécifiquement JAK2/3 dans WB, ELISA et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour JAK2/3 anticorps (pTyr939, pTyr966) (ABIN7229208)

Antigène: JAK2/3 (Janus Kinase 2/3 (JAK2/3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JAK2/3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-JAK2/3 anticorps

Épitope: pTyr939, pTyr966

Fonction: Rabbit Anti-JAK2/3 (Phospho-Tyr966/939) Polyclonal Antibody

Specificité: The antibody detects endogenous levels of JAK2/3 when Phospho occurs at Tyr966/939(human) or Tyr966/935(mouse/rat) , It doesn't react with total protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human JAK2/3 (Phospho-Tyr966/939) Antibody protein at AA range: T966

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur JAK2/3

Antigène: JAK2/3 (Janus Kinase 2/3 (JAK2/3))

Autre désignation: JAK2/3

Sujet: Tyrosine-protein kinase JAK2/JAK3, Janus kinase 2/Janus kinase 3, JAK-2/JAK-3JAK2 is a kinase that is misregulated or mutated in a number of myeloproliferative diseases and cancers. The mutation V617F is the most clinically relevant variant, and is seen in around half of myeloproliferative disorders. The variant is a known activating mutation, and activated JAK2 is sufficient to drive myeloproliferative disorders in mouse models. V617F, while most recurrent, is not the only mechanism by which JAK2 can be activated in patients. JAK2 is now one of the first diagnostic markers tested upon diagnosis with a myeloproliferative disorder.

ID gène: 1132, 1124

UniProt: O60674, P52333