MPHOSPH8 anticorps (AA 290-370)

N° du produit ABIN7229744

Cet anticorps Lapin Polyclonal détecte spécifiquement MPHOSPH8 dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MPHOSPH8 anticorps (AA 290-370) (ABIN7229744)

Antigène: MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MPHOSPH8 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MPHOSPH8 anticorps

Épitope: AA 290-370

Fonction: Rabbit Anti-MPP8 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of MPP8 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human MPP8 protein at AA range: 290-370

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur MPHOSPH8

Antigène: MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))

Autre désignation: MPP8

Sujet: M-phase phosphoprotein 8, Two hybrid-associated protein 3 with RanBPM, Twa3MPHOSPH8 (M-Phase Phosphoprotein 8) is a Protein Coding gene. Heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites, these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.

Poids moléculaire: 94kD

ID gène: 54737

UniProt: Q99549