MUM1 anticorps (AA 661-710)

N° du produit ABIN7226826

Cet anticorps anti-MUM1 Polyclonal Lapin (ABIN7226826) détecte spécifiquement MUM1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MUM1 anticorps (AA 661-710) (ABIN7226826)

Antigène: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUM1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MUM1 anticorps

Épitope: AA 661-710

Fonction: MUM1 Polyclonal Antibody

Specificité: MUM1 Polyclonal Antibody detects endogenous levels of MUM1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from MUM1 at AA range: 661-710

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000-1:20000).

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur MUM1

Antigène: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Autre désignation: MUM1

Sujet: Rabbit Anti-MUM1 Polyclonal Antibody,melanoma associated antigen (mutated) 1,DNA double-strand breaks (DSBs) are potentially hazardous lesions that can be induced by ionizing radiation (IR), radiomimetic chemicals, or DNA replication inhibitors. Melanoma associated antigen (mutated) 1 (MUM1, EXPAND1) is a PWWP-domain containing chromatin binding protein involved in maintaining chromatin architecture of interphase chromosomes. In response to DNA damage, EXPAND1/MUM1 accumulates at sites of DNA double strand breaks through direct interaction with DNA repair factor 53BP1. Accumulation of EXPAND1/MUM1 at damaged DNA sites is thought to modify the structure of the chromatin and allow access to other DNA repair factors. 53BP1 activates the checkpoint kinase ATM and promotes DNA double strand break repair via nonhomologous end joining (NHEJ) repair pathway.,MUM1

Poids moléculaire: observerd band 78kDa

ID gène: 84939

UniProt: Q2TAK8

Pathways: Chromatin Binding