NUB1 anticorps (AA 540-620)

N° du produit ABIN7216142

Cet anticorps anti-NUB1 est un anticorps Lapin Polyclonal détectant NUB1 dans WB, ELISA et IHC (p). Adapté pour Humain, Souris et Singe.

Aperçu rapide pour NUB1 anticorps (AA 540-620) (ABIN7216142)

Antigène: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Reactivité: Humain, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-NUB1 anticorps

Épitope: AA 540-620

Fonction: NUB1 Polyclonal Antibody

Specificité: NUB1 Polyclonal Antibody detects endogenous levels of NUB1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from the C-terminal region of human NUB1 at AA range: 540-620

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur NUB1

Antigène: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Autre désignation: NUB1

Sujet: Rabbit Anti-NUB1 Polyclonal Antibody,NUB1, NYREN18, NEDD8 µLtimate buster 1, Negative regulator of ubiquitin-like proteins 1, Renal carcinoma antigen NY-REN-18,NUB1 encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. Negative regulator of ubiquitin like proteins 1 encoded by NUB1 regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. Negative regulator of ubiquitin like proteins 1 interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with negative regulator of ubiquitin like proteins 1, which may contribute to the pathogenesis. Negative regulator of ubiquitin like proteins 1 is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of NUB1 results in multiple transcript variants.,NEDD8 µLtimate buster 1

Poids moléculaire: observerd band 70kDa

ID gène: 51667

UniProt: Q9Y5A7