NBR1 anticorps

N° du produit ABIN7212362

L’anticorps anti-NBR1 Monoclonal Souris est utilisé pour la détection de NBR1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour IHC et IF.

Aperçu rapide pour NBR1 anticorps (ABIN7212362)

Antigène: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NBR1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 7C3

Détail du produit anti-NBR1 anticorps

Fonction: Mouse Anti-NBR1 Mouse Monoclonal Antibody (7C3)

Specificité: The antibody detects endogenous NBR1 protein.

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Recombinant Protein of NBR1

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:50-200,IHC 1:50-300

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur NBR1

Antigène: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Autre désignation: NBR1

Sujet: Next to BRCA1 gene 1 protein, Cell migration-inducing gene 19 protein, Membrane component chromosome 17 surface marker 2, Neighbor of BRCA1 gene 1 protein, Protein 1A1-3BThe protein encoded by NBR1 (NBR1, autophagy cargo receptor) was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. NBR1 is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of NBR1 results in multiple transcript variants.

Poids moléculaire: 120kD

ID gène: 4077

UniProt: Q14596

Pathways: Autophagy