NSG2 anticorps (AA 10-90)

N° du produit ABIN7223076

Cet anticorps Lapin Polyclonal détecte spécifiquement NSG2 dans IHC, ELISA, WB et IF. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour NSG2 anticorps (AA 10-90) (ABIN7223076)

Antigène: NSG2 (HMP19) (Neuron-Specific Protein Family Member 2 (HMP19))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NSG2 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-NSG2 anticorps

Épitope: AA 10-90

Fonction: Rabbit Anti-HMP19 Polyclonal Antibody

Specificité: HMP19 Polyclonal Antibody detects endogenous levels of HMP19 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the Internal region of human HMP19 at AA range: 10-90

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur NSG2

Antigène: NSG2 (HMP19) (Neuron-Specific Protein Family Member 2 (HMP19))

Autre désignation: HMP19

Sujet: NSG2, Neuron-specific protein family member 2, Protein p19, Hmp19The chondroitin sulfate proteoglycan NG2 is a type I membrane protein expressed by subpopulations of glia including oligodendroglial precursor cells and a variety of tumor cells. Normal precursor cells and malignant tumor cells migrate and proliferate, but there is evidence that cells may not be able to engage in both activities at the same time. However, NG2 is involved in promoting both proliferation and motility. The extracellular domain of NG2 sequesters growth factors and binds to both growth factor receptors and extracellular matrix ligands such as fibronectin, collagens and laminin. The cytoplasmic domain is involved in activating Rac, Cdc42 and p130 Cas. PKCα phosphorylates NG2 at Thr2256, triggering the redistribution of NG2 from apical microprocesses to lamellipodia accompanied by enhanced cell motility. ERK phosphorylates NG2 at Thr2314, stimulating cell proliferation.

Poids moléculaire: 19kD

ID gène: 51617

UniProt: Q9Y328