NARF anticorps (AA 230-310)

N° du produit ABIN7221022

Cet anticorps Lapin Polyclonal détecte spécifiquement NARF dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour NARF anticorps (AA 230-310) (ABIN7221022)

Antigène: NARF (Nuclear Prelamin A Recognition Factor (NARF))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NARF est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-NARF anticorps

Épitope: AA 230-310

Fonction: NARF Polyclonal Antibody

Specificité: NARF Polyclonal Antibody detects endogenous levels of NARF protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from the Internal region of human NARF at AA range: 230-310

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur NARF

Antigène: NARF (Nuclear Prelamin A Recognition Factor (NARF))

Autre désignation: NARF

Sujet: Rabbit Anti-NARF Polyclonal Antibody,NARF, Nuclear prelamin A recognition factor, Iron-only hydrogenase-like protein 2, IOP2,Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The nuclear prelamin A recognition factor encoded by NARF binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.,Nuclear prelamin A recognition factor

Poids moléculaire: observerd band 51kDa

ID gène: 26502

UniProt: Q9UHQ1