P35 (AA 30-110) anticorps

N° du produit ABIN7216376

Cet anticorps anti-not_set est un anticorps Lapin Polyclonal détectant not_set dans WB, ELISA, IF et IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour P35 (AA 30-110) anticorps (ABIN7216376)

Antigène: P35

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit

Épitope: AA 30-110

Fonction: p35 Polyclonal Antibody

Specificité: P35 Polyclonal Antibody detects endogenous levels of p35 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from the N-terminal region of human p35 at AA range: 30-110

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:20000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détail du antigène

Antigène: P35

Classe de substances: Viral Protein

Sujet: Rabbit Anti-p35 Polyclonal Antibody,CDK5R1, CDK5R, NCK5A, Cyclin-dependent kinase 5 activator 1, CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit,Cyclin dependent kinase 5 regulatory subunit 1 encoded by CDK5R1 (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5), the activation of CDK5 is required for proper development of the central nervous system. The p35 form of cyclin dependent kinase 5 regulatory subunit 1 is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.,Cyclin-dependent kinase 5 activator 1

Poids moléculaire: observerd band 38kDa

ID gène: 8851

UniProt: Q15078