PTAFR anticorps (AA 170-250)

N° du produit ABIN7223724

L’anticorps anti-PTAFR Polyclonal Lapin est utilisé pour la détection de PTAFR dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA et IF.

Aperçu rapide pour PTAFR anticorps (AA 170-250) (ABIN7223724)

Antigène: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTAFR est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Détail du produit anti-PTAFR anticorps

Épitope: AA 170-250

Fonction: Rabbit Anti-PAF-R Polyclonal Antibody

Specificité: PAF-R Polyclonal Antibody detects endogenous levels of PAF-R protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the Internal region of human PAF-R at AA range: 170-250

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:200-1:1000,ELISA 1:10000,Not yet tested in other applications,

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur PTAFR

Antigène: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Autre désignation: PAF-R

Sujet: PTAFR, PAFR, Platelet-activating factor receptor, PAF-R, PAFrPTAFR (platelet activating factor receptor) encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

ID gène: 5724

UniProt: P25105

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin