ARHGAP11A anticorps (AA 440-520)

N° du produit ABIN7226098

L’anticorps anti-ARHGAP11A Polyclonal Lapin est utilisé pour la détection de ARHGAP11A dans des échantillons de Humain et Souris. Il a été validé pour ELISA et WB.

Aperçu rapide pour ARHGAP11A anticorps (AA 440-520) (ABIN7226098)

Antigène: ARHGAP11A (rho GTPase Activating Protein 11A (ARHGAP11A))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARHGAP11A est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-ARHGAP11A anticorps

Épitope: AA 440-520

Fonction: Rabbit Anti-ARHGAP11A Polyclonal Antibody

Specificité: ARHGAP11A Polyclonal Antibody detects endogenous levels of ARHGAP11A protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the Internal region of human ARHGAP11A at AA range: 440-520

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur ARHGAP11A

Antigène: ARHGAP11A (rho GTPase Activating Protein 11A (ARHGAP11A))

Autre désignation: ARHGAP11A

Sujet: ARHGAP11A, KIAA0013, Rho GTPase-activating protein 11A, Rho-type GTPase-activating protein 11AGTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. ARHGAP11A (Rho GTPase activating protein 11A), also known as KIAA0013 or MGC70740, is a 1,023 amino acid protein that contains one helical Rho-GAP domain and is encoded by a gene located on human chromosome 15. Defects in the gene encoding ARHGAP11A may cause mental retardation. Human chromosome 15 encodes over 700 genes and comprises nearly 3 % of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene.

Poids moléculaire: 110kD

ID gène: 9824

UniProt: Q6P4F7