RNF111 anticorps (AA 870-950)

N° du produit ABIN7223318

L’anticorps anti-RNF111 Polyclonal Lapin est utilisé pour la détection de RNF111 dans des échantillons de Humain et Souris. Il a été validé pour WB et ELISA.

Aperçu rapide pour RNF111 anticorps (AA 870-950) (ABIN7223318)

Antigène: RNF111 (Ring Finger Protein 111 (RNF111))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF111 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-RNF111 anticorps

Épitope: AA 870-950

Fonction: Rabbit Anti-Arkadia Polyclonal Antibody

Specificité: Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the C-terminal region of human Arkadia at AA range: 870-950

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur RNF111

Antigène: RNF111 (Ring Finger Protein 111 (RNF111))

Autre désignation: Arkadia

Sujet: RNF111, E3 ubiquitin-protein ligase Arkadia, RING finger protein 111The protein encoded by RNF111 (ring finger protein 111) is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF)-beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of RNF111 results in multiple transcript variants encoding distinct isoforms.

Poids moléculaire: 110kD

ID gène: 54778

UniProt: Q6ZNA4