SKIL anticorps (AA 590-670)

N° du produit ABIN7217066

L’anticorps anti-SKIL Polyclonal Lapin est utilisé pour la détection de SKIL dans des échantillons de Humain et Souris. Il a été validé pour WB, ELISA, IHC et IF.

Aperçu rapide pour SKIL anticorps (AA 590-670) (ABIN7217066)

Antigène: SKIL (SKI-Like Oncogene (SKIL))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SKIL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-SKIL anticorps

Épitope: AA 590-670

Fonction: Rabbit Anti-SnoN Polyclonal Antibody

Specificité: SnoN Polyclonal Antibody detects endogenous levels of SnoN protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the C-terminal region of human SnoN at AA range: 590-670

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur SKIL

Antigène: SKIL (SKI-Like Oncogene (SKIL))

Autre désignation: SnoN

Sujet: SKIL, SNO, Ski-like protein, Ski-related oncogene, Ski-related proteinSki-like protein encoded by SKIL is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.

Poids moléculaire: 77kD

ID gène: 6498

UniProt: P12757

Pathways: Positive Regulation of Response to DNA Damage Stimulus