SMAD7 anticorps

N° du produit ABIN7231402

Cet anticorps anti-SMAD7 Polyclonal Lapin (ABIN7231402) détecte spécifiquement SMAD7 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SMAD7 anticorps (ABIN7231402)

Antigène: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD7 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SMAD7 anticorps

Fonction: SMAD7 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of SMAD7 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogène: Synthesized peptide derived from part region of human SMAD7 protein

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur SMAD7

Antigène: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Autre désignation: SMAD7

Sujet: Rabbit Anti-SMAD7 Polyclonal Antibody,Mothers against decapentaplegic homolog 7, MAD homolog 7, Mothers against DPP homolog 7, Mothers against decapentaplegic homolog 8, MAD homolog 8, Mothers against DPP homolog 8, SMAD family member 7, SMAD 7, Smad7, hSMAD7,The protein encoded by SMAD7 is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of SMAD7 is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for SMAD7.,SMAD7

Poids moléculaire: observerd band 46kDa

ID gène: 4092

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization