VRK1 anticorps

N° du produit ABIN7232118

Cet anticorps anti-VRK1 Polyclonal Lapin (ABIN7232118) détecte spécifiquement VRK1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour VRK1 anticorps (ABIN7232118)

Antigène: VRK1 (Vaccinia Related Kinase 1 (VRK1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VRK1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-VRK1 anticorps

Fonction: Rabbit Anti-VRK1 Polyclonal Antibody

Specificité: The antibody detects endogenous levels of VRK1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human VRK1 protein

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur VRK1

Antigène: VRK1 (Vaccinia Related Kinase 1 (VRK1))

Autre désignation: VRK1

Sujet: Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. VRK1 is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 Molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. VRK1, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Poids moléculaire: 43kD

ID gène: 7443

UniProt: Q99986