NALCN anticorps (C-Term)

N° du produit ABIN7232810

L’anticorps anti-NALCN Monoclonal Souris est utilisé pour la détection de NALCN dans des échantillons de Rat. Il a été validé pour WB et IF/ICC.

Aperçu rapide pour NALCN anticorps (C-Term) (ABIN7232810)

Antigène: NALCN (Sodium Leak Channel, Non-Selective (NALCN))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NALCN est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (fixed cells) (IF/ICC)

Clone: S185-7

Détail du produit anti-NALCN anticorps

Épitope: AA 1659-1738, C-Term

Fonction: Anti-NALCN Mouse Monoclonal Antibody

Specificité: This antibody recognizes mouse and rat NALCN.

Réactivité croisée: Souris, Rat

Purification: Purified by Protein G affinity chromatography.

Immunogène: Fusion protein corresponding to aa 1659-1738 (cytoplasmic C- terminus) of rat NALCN (accession no.Q6Q760).

Isotype: IgG1

Information d'application

Indications d'application: Immunoblotting: use at 1 μg/mL. Predicted molecular weight is ~200 kDa.
Positive control: rat brain lysate.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium which is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This antibody is stable for at least one (1) year at -20°C.

Détails sur NALCN

Antigène: NALCN (Sodium Leak Channel, Non-Selective (NALCN))

Autre désignation: Nalcn

Sujet: Sodium leak channel NALCN,Voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability. NALCN channel functions as a multi-protein complex, which consists at least of NALCN, NALF1, UNC79 and UNC80. NALCN is the voltage-sensing, pore-forming subunit of the NALCN channel complex. NALCN channel complex is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (By similarity). In addition to its role in regulating neuronal excitability, is required for normal respiratory rhythm, systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal. NALCN channel is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway. In addition, NALCN activity is enhanced/modulated by several GPCRs, such as CHRM3 (By similarity). {UniProtKB:Q8BXR5, UniProtKB:Q8IZF0}.,NALCN (sodium leak channel non- selective protein) is a 1,738 amino acid multi-pass membrane protein in the cation-nonselective channel family. NALCN is highly conserved in mammalian species and is widely expressed in the central nervous system. NALCN is a voltage-independent, non-selective cation channel which is permeable to sodium, potassium, and calcium ions. It is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous system. Three isoforms of NALCN result from alternative splicing events.,Cell membrane, Multi-pass membrane protein,Four domain-type voltage-gated ion channel α-1 subunit, Rb21-channel, Sodium leak channel non-selective protein, Voltage gated channel-like protein 1

NCBI Accession: NP_705894

UniProt: Q6Q760