FPR1 anticorps

N° du produit ABIN7232897

L’anticorps Souris Monoclonal anti-FPR1 a été validé pour WB et IF. Il convient pour détecter FPR1 dans des échantillons de Humain.

Aperçu rapide pour FPR1 anticorps (ABIN7232897)

Antigène: FPR1 (Formyl Peptide Receptor 1 (FPR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FPR1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: NFPR1

Détail du produit anti-FPR1 anticorps

Fonction: Anti-FPR1/2 MAb Mouse Monoclonal Antibody

Specificité: This antibody recognizes human FPR1 at aa 305-GQDFRERLI-313 at the amino- terminal portion of the carboxyl-terminal tail. It also recognizes the same epitope in FPR2.

Réactivité croisée: Humain

Immunogène: His-tagged recombinant FPR1 (human neutrophil N-formyl peptide receptor 1) expressed in and purified from Sf9 cells.

Isotype: IgG1

Information d'application

Indications d'application: Immunoblotting: use at 1-5 μg/mL.
Immunofluorescence: use at 10 μg/mL.
These are recommended concentrations.
Enduser should determine optimal concentrations for their application.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: Lot specific

Buffer: PBS, pH 7.4

Stock: -20 °C,-80 °C

Stockage commentaire: This product is stable for at least one (1)year at -20°C to -70 C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Détails sur FPR1

Antigène: FPR1 (Formyl Peptide Receptor 1 (FPR1))

Autre désignation: FPR1

Sujet: FMet-Leu-Phe receptor,High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520, PubMed:15210802). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium sPubMed:10514456, PubMed:15153520, PubMed:2161213, PubMed:2176894, PubMed:25109685, PubMed:10514456, PubMed:1712023, PubMed:2161213, PubMed:2176894}.,Formyl peptide receptors (FPR) are G protein-coupled receptors that are activated by different agonists included N- formylated peptides originating from bacteria and mitochondria. In humans, the FPR family includes the high affinity FPR1, the low affinity FPR2/ALX (previously known as FPRL1 or ALX) and FPR3. Human FPR1 is important for phagocyte chemotaxis, superoxide production, and degranulation, and helps direct phagocytes to sites of infection. Functional FPR1expression has been demonstrated on fibroblasts, bone marrow mesenchymal stem cells, A549 lung cells, HEP-G2 hepatoma cells, and on several types of epithelial cells.,Cell membrane,fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor

UniProt: P21462