Neuroligin 1 anticorps (C-Term)

N° du produit ABIN7233049

Cet anticorps Souris Monoclonal détecte spécifiquement Neuroligin 1 dans WB, IHC et IF/ICC. Il présente une réactivité envers Rat.

Aperçu rapide pour Neuroligin 1 anticorps (C-Term) (ABIN7233049)

Antigène: Neuroligin 1 (NLGN1)

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Neuroligin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC)

Clone: S97A-31

Détail du produit anti-Neuroligin 1 anticorps

Épitope: AA 718-843, C-Term

Fonction: Anti-Neuroligin-1 Mouse Monoclonal Antibody

Specificité: This antibody recognizes human, mouse, and rat Neuroligin-1. It does not cross- react with other Neuroligins.

Réactivité croisée: Humain, Souris, Rat

Immunogène: Fusion protein corresponding to aa 718-843 (cytoplasmic C-terminus) of rat Neuroligin- 1, accession no. Q62765). This sequence is 99

Isotype: IgG1

Information d'application

Indications d'application: Immunoblotting: use at 1-5 μg/mL. A band of ~120 kDa is detected.
Immunofluorescence: use at 10 μg/mL.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 0.1 % sodium azide, 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This product is stable for at least one (1) year at -20°C.

Détails sur Neuroligin 1

Antigène: Neuroligin 1 (NLGN1)

Autre désignation: Nlgn1

Sujet: Neuroligin-1,Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development. {UniProtKB:Q99K10, PubMed:15620359, PubMed:9325340}.,Neuroligin-1 is a neuronal cell surface protein and member of the type-B carboxylesterase/lipase family. It is a necessary component in the maturation of excitatory synapses, it participates in regulation of synaptic plasticity, and it is important in the development of long- term memory in adult mammalian amygdala. It's participation in cell-cell interactions may occur through assembly of intracellular junctions by binding of beta-neurexins. In nervous system tissue, Neuroligin-1 is observed primarily in neurons and in the spinal cord.,Cell membrane, Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density, Cell junction, synapse, synaptic cleft, Cell junction, synapse, synaptic cell membrane,Neuroligin I

UniProt: Q62765

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis