GABARAPL1 anticorps (C-Term)

N° du produit ABIN7233060

Cet anticorps anti-GABARAPL1 est un anticorps Lapin Polyclonal détectant GABARAPL1 dans WB et IF/ICC. Adapté pour Humain.

Aperçu rapide pour GABARAPL1 anticorps (C-Term) (ABIN7233060)

Antigène: GABARAPL1 (GABA(A) Receptor-Associated Protein Like 1 (GABARAPL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABARAPL1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (fixed cells) (IF/ICC)

Détail du produit anti-GABARAPL1 anticorps

Épitope: C-Term

Fonction: Anti-GABARAPL1 Rabbit Polyclonal Antibody

Specificité: This antibody recognizes human GABARAPL1.

Réactivité croisée: Humain

Immunogène: Synthetic peptide corresponding to the C-terminus of human GABARAPL1

Information d'application

Indications d'application: Immunoblotting: use at dilution of 1:1,000. A band of ~14-16 kDa is detected.
Immunofluorescence: use at dilution of 1:100
These are recommended working dilutions.
Endusers should determine optimal dilutions for their applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This antibody is stable for at least one (1) year at -20°C.

Détails sur GABARAPL1

Antigène: GABARAPL1 (GABA(A) Receptor-Associated Protein Like 1 (GABARAPL1))

Autre désignation: GABARAPL1

Sujet: γ-aminobutyric acid receptor-associated protein-like 1,Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). {PubMed:16431922, PubMed:20404487, PubMed:31006537, PubMed:31006538}.,GABARAP, GABARAPL1 and GABARAPL2 genes are differentially expressed in normal and pathological tissues. The GABARAP gene is highly expressed in endocrine tissues while the GABARAPL1 gene is predominantly expressed in the central nervous system, but they both are underexpressed in a large variety of cancer cell lines. However, the analysis of GABARAPL1 expression in a cohort of 256 breast adenocarcinoma revealed that a low GABARAPL1 expression was correlated with a high risk of metastasis, in particular for lymph node-positive patients.,Cytoplasmic vesicle, autophagosome, Cytoplasmic vesicle membrane, Cytoplasm, cytoskeleton, Endoplasmic reticulum, Golgi apparatus,Early estrogen-regulated protein, GABA(A receptor-associated protein-like 1, Glandular epithelial cell protein 1, GEC-1

UniProt: Q9H0R8

Pathways: Autophagy