CALCRL anticorps (Extracellular, N-Term) (FITC)

N° du produit ABIN7237607

Cet anticorps Lapin Polyclonal détecte spécifiquement CALCRL dans FACS et LCI. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CALCRL anticorps (Extracellular, N-Term) (FITC) (ABIN7237607)

Antigène: CALCRL (Calcitonin Receptor-Like (CALCRL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CALCRL est conjugé à/à la FITC

Application: Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-CALCRL anticorps (FITC)

Épitope: AA 127-140, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to CRLR/CALCRL (extracellular) conjugated to the fluorescent dye FITC

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,rat - 12 out of 14 amino acid residues identical

Attributs du produit: Extracellular, N-terminus

Purification: Affinity purified on immobilized antigen.

Immunogène: CNVNTHEKVKTALN, corresponding to amino acid residues 127 - 140 of human Calcitonin Receptor-Like Receptor 

Isotype: IgG

Information d'application

Indications d'application:

WB: The optimal concentration should be determined by the user

FC: 2.5-5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7582044)

Blocking Peptide: (ABIN7234904)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 15 μL or 50 μL double distilled water (DDW), depending on the sample size.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CALCRL

Antigène: CALCRL (Calcitonin Receptor-Like (CALCRL))

Autre désignation: CALCRL

Sujet:

Synonyms: Calcitonin Receptor-Like Receptor, Calcitonin Gene-Related Peptide Type 1 Receptor, CRL, CGRPR

Description: Calcitonin Receptor-Like Receptor 1 (CRLR or CGRPR) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism1.When engaged with its substrate, calcitonin gene related peptide (CGRP), CGRPR activates cAMP-dependent pkA and PI3 kinase, which eventually leads to complex inhibitory as well as facilitator actions on Neuronal Nicotinic Acetylcholine Receptor1.CGRP receptor is a heterodimer composed of two proteins: a 7-transmembrane domain type 2 G-protein coupled receptor called calcitonin-receptor-like receptor (CRLR), and receptor-activity-modifying protein 1 (RAMP1), a single-membrane-pass protein. RAMP1 serves as a transporter for CRLR to the cell surface and its absence leads to failure of binding with CRLR2.CGRP and CGRPR are ubiquitously expressed and their interaction is related to various diseases and health states such as migraines3 and Alzheimer's disease1.

ID gène: 10203

NCBI Accession: NM_032513

UniProt: Q16602

Pathways: cAMP Metabolic Process