GPR139 anticorps (Intracellular, Loop 3)

N° du produit ABIN7237648

Cet anticorps Lapin Polyclonal détecte spécifiquement GPR139 dans IHC et WB. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour GPR139 anticorps (Intracellular, Loop 3) (ABIN7237648)

Antigène: GPR139 (G Protein-Coupled Receptor 139 (GPR139))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPR139 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Détail du produit anti-GPR139 anticorps

Épitope: AA 204-217, Intracellular, Loop 3

Fonction: A Rabbit Polyclonal antibody to Parkin

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,Human - identical

Attributs du produit: Intracellular, 3rd loop

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RKSNFRLRGYSTGK, corresponding to amino acid residues 204 - 217 of mouse GPR139 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:800

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:600

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235369)

Blocking Peptide: (ABIN7235369)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur GPR139

Antigène: GPR139 (G Protein-Coupled Receptor 139 (GPR139))

Autre désignation: GPR139 

Sujet:

Synonyms: G Protein-Coupled Receptor 139, PGR3, G(Q)-Coupled Orphan Receptor GPRg1, GPRG1

Description: G-protein-coupled receptors (GPCRs), are the largest family of membrane proteins and mediate most of the physiological responses to hormones, neurotransmitters and environmental stimulants. At the most basic level, all GPCRs are characterized by the presence of seven membrane-spanning α-helical segments separated by alternating intracellular and extracellular loop regions1. Orphan GPCRs are a group of GPCRs that their endogenous ligands remain unidentified and therefore their natural functions in doubt2.GPR139 is an orphan GPCRs for which amino acids L-tryptophan and L-phenylalanine, the adrenocorticotropic hormone (ACTH), and α- and β-melanocyte-stimulating hormone have been proposed as endogenous agonists3. GPR139 was found to be highly conserved across species, as the amino acid sequence of the human GPR139 protein is 96 % , 92 % and 70 % identical to the mouse, chicken and zebrafish orthologs, respectively. According to mRNA expression levels GPR139 is mainly expressed in the central nervous system (CNS). GPR139 has been reported to activate several G protein pathways of which Gq/11 is the primary one4.

ID gène: 209776

NCBI Accession: NM_001002911

UniProt: Q80UC8