LRRC4 anticorps (Extracellular, N-Term)

N° du produit ABIN7237706

L’anticorps anti-LRRC4 Polyclonal Lapin est utilisé pour la détection de LRRC4 dans des échantillons de Souris. Il a été validé pour WB, IHC, FACS et LCI.

Aperçu rapide pour LRRC4 anticorps (Extracellular, N-Term) (ABIN7237706)

Antigène: LRRC4 (Leucine Rich Repeat Containing 4 (LRRC4))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRRC4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-LRRC4 anticorps

Épitope: AA 507-520, Extracellular, N-Term

Fonction: A Rabbit Polyclonal antibody to NGL-2/LRRC4 (extracellular)

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat - identical,Human 13 out of 14 amino acid residues identical

Attributs du produit: Extracellular, N-terminus

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)STDTTDKMQTSLDE, corresponding to amino acid residues 507 - 520 of mouse LRRC4

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235857)

Blocking Peptide: (ABIN7235857)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur LRRC4

Antigène: LRRC4 (Leucine Rich Repeat Containing 4 (LRRC4))

Autre désignation: LRRC4 

Sujet:

Synonyms: Netrin-G2 Ligand, Brain Tumor-Associated Protein BAG, Leucine-Rich Repeat-Containing Protein 4

Description: The leucine-rich repeat (LRR) superfamily is a diverse protein family that consist of leucine-rich domains (LRR domains). The LRR domain is known to regulate protein-protein interaction or cell adhesion. Large portion of LRR proteins mediate the differentiation and development of nervous tissues1. One member of the LRR superfamily is leucine rich repeat containing protein 4 (LRRC4), also known as netrin-G ligand-2 (NGL-2), and serves as a receptor for netrin-G2 (NTNG2). In addition to the LRR domain LRRC4 consist of immunoglobulin (Ig) domain in the extracellular region, a transmembrane domain, and a cytoplasmic region that terminates in a protein-protein interaction domain (PDZ)-binding motif. LRRC4 regulates the formation of excitatory synapses and promotes axon differentiation2.Functionally, deletion of LRRC4 in mice was found to suppress excitatory synapse development and synaptic transmission. In addition, LRRC4 gene has been identified as tumor suppressor3. In human it has been implicated in autism spectrum disorder (ASD), schizophrenia, and intellectual disability. Moreover, netrin-G2, the presynaptic ligand of LRRC4, is linked to schizophrenia and bipolar disorder4-5.

ID gène: 192198

NCBI Accession: NM_022143

UniProt: Q99PH1

Pathways: Synaptic Membrane