NPY1R anticorps (Extracellular) (FITC)

N° du produit ABIN7237741

Cet anticorps Lapin Polyclonal détecte spécifiquement NPY1R dans FACS et LCI. Il présente une réactivité envers Souris.

Aperçu rapide pour NPY1R anticorps (Extracellular) (FITC) (ABIN7237741)

Antigène: NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPY1R est conjugé à/à la FITC

Application: Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-NPY1R anticorps (FITC)

Épitope: AA 197-210, Extracellular

Fonction: A Rabbit Polyclonal Antibody to NPY1R (extracellular) conjugated to the fluorescent dye FITC

Specificité: 2nd extracellular loop

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat - identical, human - 13,14 amino acid residues identical

Attributs du produit: Extracellular, 2nd loop

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: CFDKFPSDSHRLSY, corresponding to amino acid residues 197-210 of mouse NPY1R

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: N/A

Commentaires:

Negative Control: (ABIN7582044)

Blocking Peptide: (ABIN7236090)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 15 μL or 50 μL double distilled water (DDW), depending on the sample size.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur NPY1R

Antigène: NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))

Autre désignation: NPY1R

Sujet: Neuropeptide Y receptor type 1, NPYR, NPYY1,Neuropeptide Y1 receptor (NPY1R) is one out of four receptors (NPY1R, NPY2R, NPY4R and NPY5R) that bind neuropeptide Y (NPY), an abundant neuropeptide in the mammalian central and peripheral nervous systems.NPY1R is part of the β-branch of class A G-protein coupled receptors and likewise, has seven transmembrane domains with an extracellular N-terminus and intracellular C-terminal tail1,2.NPY belongs to a family of gut-brain peptides that demonstrate both hormonal functions by paracrine and endocrine release in the gastrointestinal tract and a neurotransmitter functions in sympathetic ganglia and the CNS. It is highly expressed throughout the brain with particularly high expression in limbic brain areas, such as the hippocampus, amygdala, and hypothalamus3,4. NPY modulates multiple physiological and pathophysiological processes: it increases food intake and reduces fear and anxiety by activating NPY1R1,2.Because of the multiple functions of NPY, NPY1R has great importance in the development and progression of both metabolic and neurological diseases such as diabetes, obesity, breast cancer and bone loss and indeed a number of peptides and small-molecule compounds have been characterized as NPY1R antagonists and have shown clinical potential in the treatment of these pathological states5.

Alternative names: Neuropeptide Y receptor type 1, NPYR, NPYY1

ID gène: 18166

NCBI Accession: NM_000909

UniProt: Q04573

Pathways: Negative Regulation of Hormone Secretion, Feeding Behaviour