Plexin C1 anticorps (Extracellular, N-Term) (FITC)

N° du produit ABIN7237768

Cet anticorps Lapin Polyclonal détecte spécifiquement Plexin C1 dans FACS et LCI. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Plexin C1 anticorps (Extracellular, N-Term) (FITC) (ABIN7237768)

Antigène: Plexin C1 (PLXNC1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Plexin C1 est conjugé à/à la FITC

Application: Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-Plexin C1 anticorps (FITC)

Épitope: AA 860-874, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to PLXNC1 (extracellular) conjugated to the fluorescent dye FITC

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse - identical Rat - 14 out of 15 amino acid residues identical

Attributs du produit: Extracellular, N-terminus

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)EVKIQKENDNFNISK, corresponding to amino acid residues 860 - 874 of human Plexin-C1

Isotype: IgG

Information d'application

Indications d'application:

WB: The optimal concentration should be determined by the user

FC: 2.5-5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7582044)

Blocking Peptide: (ABIN7236272)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Plexin C1

Antigène: Plexin C1 (PLXNC1)

Autre désignation: PLXNC1

Sujet:

Synonyms: Virus-Encoded Semaphorin Protein Receptor, VESPR, CD232, PLXNC1

Description: Plexin-C1 also known as Virus-encoded semaphorin protein receptor, is a ~210 kDa type I transmembrane receptor that regulates cytoskeletal remodeling and adhesion in human melanocytes.It belongs to the family of Plexin receptors, these are type I transmembrane proteins (A-D) that share a highly conserved cytoplasmic domain and an intracellular region containing an intrinsic Ras-GTPase activating (GAP) domain. Plexin receptors bind semaphorins: a class of secreted and membrane proteins 1. The natural ligand of Plexin C1 is Semaphorin -7A (#ASR-077).Plexin-C1 is highly expressed in melanocytes, neurons, neutrophils, dendritic cells and pre-osteoblasts and it has a complex effect on migration of melanocytes and melanoma, that depends on the phase of progression of this type of cancer 2,3. It also has additional roles in the partitioning of paraventricular and supraoptic neurons in the hypothalamus, in the development of inflamation and in inhibition of neutrophils phagocytosis 3,4.

ID gène: 10154

NCBI Accession: NM_005761

UniProt: O60486