SSTR3 anticorps (Intracellular)

N° du produit ABIN7237867

L’anticorps Lapin Polyclonal anti-SSTR3 a été validé pour WB, IHC et IF. Il convient pour détecter SSTR3 dans des échantillons de Rat.

Aperçu rapide pour SSTR3 anticorps (Intracellular) (ABIN7237867)

Antigène: SSTR3 (Somatostatin Receptor 3 (SSTR3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SSTR3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-SSTR3 anticorps

Épitope: AA 233-246, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 3

Specificité: Intracellular, between transmembrane domains 5 and 6

Réactivité croisée: Souris, Rat

Homologie: Mouse - identical, human - 11,14 amino acid residues identical

Attributs du produit: Intracellular, between transmembrane domains 5 and 6

Purification: Affinity purified on immobilized antigen.

Immunogène:

Immunogen: Synthetic peptide

Immunogen Sequence: KVRSTTRRVRAPSC, corresponding to amino acid residues 233-246 of rat SSTR3

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Commentaires:

Negative Control: (ABIN7237243)

Blocking Peptide: (ABIN7237243)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur SSTR3

Antigène: SSTR3 (Somatostatin Receptor 3 (SSTR3))

Autre désignation: SSTR3

Sujet: SSTR3, SS3R, Smstr3,Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as practically every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28 that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. SST induces in target cells a variety of physiological functions that include nueromodulation, cell secretion, cell proliferation and smooth muscle contractility.SST acts on its multiple cell targets via a family of six receptors that are originated form five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell response via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation.SSTRs are expressed widely in both the brain and peripheral tissues but with receptor subtype variations between the different cell types. Thus, SSTR3 expression in the brain is primarily concentrated in the cerebellum with lesser expression in peripheral organs such as the spleen, the liver and the pituitary.Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain.

Alternative names: Somatostatin Receptor Type 3, SSTR3, SS3R, Smstr3,

ID gène: 171044

NCBI Accession: NM_001051

UniProt: P30936