Tetraspanin 3 anticorps (Extracellular, Loop 2)

N° du produit ABIN7237881

L’anticorps anti-Tetraspanin 3 Polyclonal Lapin est utilisé pour la détection de Tetraspanin 3 dans des échantillons de Humain. Il a été validé pour WB, IHC, FACS et LCI.

Aperçu rapide pour Tetraspanin 3 anticorps (Extracellular, Loop 2) (ABIN7237881)

Antigène: Tetraspanin 3 (TSPAN3)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tetraspanin 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-Tetraspanin 3 anticorps

Épitope: AA 155-169, Extracellular, Loop 2

Fonction: A Rabbit Polyclonal antibody to Tetraspanin-3 (extracellular)

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,rat - identical

Attributs du produit: Extracellular, 2nd loop

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DWENTDWFKETKNQS, corresponding to amino acid residues 155 - 169 of human Tetraspanin-3

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237377)

Blocking Peptide: (ABIN7237377)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Tetraspanin 3

Antigène: Tetraspanin 3 (TSPAN3)

Autre désignation: TSPAN3

Sujet:

Synonyms: TSPAN3, Transmembrane 4 Superfamily Member 8, TM4SF8

Description: Tetraspanin-3, encoded by TSPAN3 gene is a membrane-spanning glycoprotein that has a role in cell migration, proliferation, and interactions between cells and extracellular matrix.As suggested by the family name, TSPANs are categorized by the presence of four trans-membrane domains, of which two are extracellular. The intracellular part includes the C and N terminal domains that can facilitate protein-protein interactions, as well as guide intracellular trafficking. TSPANs have multiple roles In the immune and vascular systems, and they act as organizers of functional microdomains and multi-subunit receptor complexes 1.Tspan3 is highly expressed in the brain and elevated in brains of Alzheimers disease (AD) patients. It was shown to interact with ADAM10, which is a marker for Alzheimer's disease 2. It was also shown to be expressed by dendritic cells (DCs) which suggests that it may be involved in the function of DCs in association with T cell stimulation 3.Its functional diversity and importance for the development and onset of various diseases makes Tetraspanin 3 an appealing research target.

ID gène: 10099

NCBI Accession: NM_005724

UniProt: O60637