TMC1 anticorps (Extracellular, Loop 3)

N° du produit ABIN7237916

Cet anticorps Lapin Polyclonal détecte spécifiquement TMC1 dans WB, FACS et LCI. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour TMC1 anticorps (Extracellular, Loop 3) (ABIN7237916)

Antigène: TMC1 (Transmembrane Channel-Like 1 (TMC1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMC1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-TMC1 anticorps

Épitope: Extracellular, Loop 3

Fonction: A Rabbit Polyclonal antibody to TMC1 (extracellular) 

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,human - identical

Attributs du produit: Extracellular, 3rd loop

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)EHDFPSWMAKILR, corresponding to amino acid residues 679 - 691 of mouse TMC1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: 2.5 mg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237509)

Blocking Peptide: (ABIN7237509)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TMC1

Antigène: TMC1 (Transmembrane Channel-Like 1 (TMC1))

Autre désignation: TMC1 

Sujet:

Synonyms: Transmembrane Channel Like 1, Transmembrane cochlear-expressed protein 1

Description: Transmembrane channel-like protein 1 (TMC1) is one of eight mammalian TMC genes. Proteins that belong to this family contain six transmembrane domains with both the C and N termini on the cytoplasmic side of the membrane, as well as a large loop between domains 4 and 5. This multi-pass transmembrane topologic structure suggests roles as a receptor, transporter, channel, or pump1. TMC1 and the closely related TMC2 gene are assembled as dimers2 and are expressed in neurosensory hair cells of the mouse inner ear where they appear to have a role as pore forming units in mechanoelectrical transduction. Mutations of the transmembrane channel-like 1 (TMC1) gene can cause dominant and recessive forms of deafness in humans and mice3 and hence, identification of the molecular functions of Tmc genes is broadly significant because it may provide a handle on the fundamental mechanisms that mediate human hearing and balance4.

ID gène: 13409

NCBI Accession: NM_138691

UniProt: Q8R4P5

Pathways: Sensory Perception of Sound