C9ORF72 anticorps (AA 1-230)

N° du produit ABIN7266391

Détail du produit anti-C9ORF72 anticorps

Antigène: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Épitope: AA 1-230

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C9ORF72 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Fonction: C9orf72 Rabbit pAb

Séquence: MSTLCPPPSP AVAKTEIALS GKSPLLAATF AYWDNILGPR VRHIWAPKTE QVLLSDGEIT FLANHTLNGE ILRNAESGAI DVKFFVLSEK GVIIVSLIFD GNWNGDRSTY GLSIILPQTE LSFYLPLHRV CVDRLTHIIR KGRIWMHKER QENVQKIILE GTERMEDQGQ SIIPMLTGEV IPVMELLSSM KSHSVPEEID IADTVLNDDD IGDSCHEGFL LNAISSHLQT

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human C9orf72 (NP_060795.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur C9ORF72

Antigène: C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))

Autre désignation: C9orf72 (C9ORF72 Produits)

Synonymes: anticorps CZH9orf72, anticorps ALSFTD, anticorps FTDALS, anticorps AI840585, anticorps c9orf72, anticorps chromosome Z C9orf72 homolog, anticorps chromosome 9 open reading frame 72, anticorps RIKEN cDNA 3110043O21 gene, anticorps similar to RIKEN cDNA 3110043O21, anticorps chromosome 9 open reading frame 72 L homeolog, anticorps CZH9orf72, anticorps C9orf72, anticorps 3110043O21Rik, anticorps RGD1359108, anticorps c9orf72.L

Sujet: The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.,C9orf72,ALSFTD,DENNL72,FTDALS,FTDALS1,Epigenetics & Nuclear Signaling,Transcription Factors,Neuroscience,Neurodegenerative Diseases,Neurodegenerative Diseases Markers,Other Neurological disorders,Amyotrophic lateral sclerosis-ALS,C9orf72

Poids moléculaire: 24kDa/54kDa

ID gène: 203228

UniProt: Q96LT7