CCDC47 anticorps (AA 224-483)

N° du produit ABIN7266438

Cet anticorps anti-CCDC47 est un anticorps Lapin Polyclonal détectant CCDC47 dans WB et IF. Adapté pour Humain.

Aperçu rapide pour CCDC47 anticorps (AA 224-483) (ABIN7266438)

Antigène: CCDC47 (Coiled-Coil Domain Containing 47 (CCDC47))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCDC47 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-CCDC47 anticorps

Épitope: AA 224-483

Fonction: CCDC47 Rabbit pAb

Séquence: FLKRQDLLNV LARMMRPVSD QVQIKVTMND EDMDTYVFAV GTRKALVRLQ KEMQDLSEFC SDKPKSGAKY GLPDSLAILS EMGEVTDGMM DTKMVHFLTH YADKIESVHF SDQFSGPKIM QEEGQPLKLP DTKRTLLFTF NVPGSGNTYP KDMEALLPLM NMVIYSIDKA KKFRLNREGK QKADKNRARV EENFLKLTHV QRQEAAQSRR EEKKRAEKER IMNEEDPEKQ RRLEEAALRR EQKKLEKKQM KMKQIKVKAM

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 224-483 of human CCDC47 (NP_064583.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CCDC47

Antigène: CCDC47 (Coiled-Coil Domain Containing 47 (CCDC47))

Autre désignation: CCDC47

Sujet: Component of the PAT complex, an endoplasmic reticulum (ER-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs, releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation pathway. Has an essential role in the maintenance of ER organization during embryogenesis (By similarity.,CCDC47,GK001,MSTP041,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,CCDC47

Poids moléculaire: 55kDa

ID gène: 57003

UniProt: Q96A33