CARS anticorps

N° du produit ABIN7266624

Cet anticorps anti-CARS est un anticorps Lapin Monoclonal détectant CARS dans WB et IHC. Adapté pour Humain.

Aperçu rapide pour CARS anticorps (ABIN7266624)

Antigène: CARS (Cysteinyl-tRNA Synthetase (CARS))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CARS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-CARS anticorps

Fonction: CARS Rabbit mAb

Réactivité croisée: Humain, Rat

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: A synthesized peptide derived from human CARS.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CARS

Antigène: CARS (Cysteinyl-tRNA Synthetase (CARS))

Autre désignation: CARS

Sujet: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.,CARS, CARS1, CYSRS, MGC:11246, cysteinyl-tRNA synthetase,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,Nucleotide metabolism,CARS

Poids moléculaire: 75kDa

ID gène: 833

UniProt: P49589