DNER anticorps (AA 140-240)

N° du produit ABIN7266727

Cet anticorps Lapin Polyclonal détecte spécifiquement DNER dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour DNER anticorps (AA 140-240) (ABIN7266727)

Antigène: DNER (delta/notch-Like EGF Repeat Containing (DNER))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNER est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-DNER anticorps

Épitope: AA 140-240

Fonction: DNER Rabbit pAb

Séquence: PATGWTESMA PRQLQPVPAT QEPDKILPRS QATVTLPTWQ PKTGQKVVEM KWDQVEVIPD IACGNASSNS SAGGRLVSFE VPQNTSVKIR QDATASLILL W

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human DNER (NP_620711.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur DNER

Antigène: DNER (delta/notch-Like EGF Repeat Containing (DNER))

Autre désignation: DNER

Sujet: DNER (Delta/Notch-like EGF-related receptor), also known as BET (brain-specific EGF-like transmembrane protein), is a type I transmembrane glycoprotein of the Notch/Delta family . In the mouse, DNER has been detected as 90, 120 and 150 kDa forms which are probably variably glycosylated .Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.DNER associates with protein tyrosine phosphatase zeta (PTP zeta ), which is the receptor of pleiotrophin (PTN). PTP zeta -PTN-DNER signaling has been implicated in the regulation of neuritogenesis. Expression of DNER in glioblastoma stem-like cells inhibits formation of neurospheres in vitro, while in vivo it induces differentiation and inhibits growth of xenografts, thus acting as a tumor suppressor.,DNER,UNQ26,bet,Neuroscience,Stem Cells,DNER

Poids moléculaire: 78kDa

ID gène: 92737

UniProt: Q8NFT8

Pathways: Skeletal Muscle Fiber Development