Doublecortin anticorps (AA 240-360)

N° du produit ABIN7266840

Cet anticorps anti-Doublecortin est un anticorps Lapin Polyclonal détectant Doublecortin dans IF. Adapté pour Humain.

Aperçu rapide pour Doublecortin anticorps (AA 240-360) (ABIN7266840)

Antigène: Doublecortin (DCX)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Doublecortin est non-conjugé

Application: Immunofluorescence (IF)

Détail du produit anti-Doublecortin anticorps

Épitope: AA 240-360

Fonction: DCX Rabbit pAb

Séquence: HDFFGDDDVF IACGPEKFRY AQDDFSLDEN ECRVMKGNPS ATAGPKASPT PQKTSAKSPG PMRRSKSPAD SANGTSSSQL STPKSKQSPI STPTSPGSLR KHKDLYLPLS LDDSDSLGDS M

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 240-360 of human DCX (NP_835364.1).

Isotype: IgG

Information d'application

Indications d'application: IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Doublecortin

Antigène: Doublecortin (DCX)

Autre désignation: DCX

Sujet: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010],DBCN;DC;LISX;SCLH;XLIS;DCX,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cell Adhesion,Microtubules,Neuroscience,Cell Type Marker,Neuron marker,Growth Cone,DCX

Poids moléculaire: 40kDa

ID gène: 1641

UniProt: O43602