EXOSC10 anticorps (AA 586-885)

N° du produit ABIN7267062

Cet anticorps anti-EXOSC10 est un anticorps Lapin Polyclonal détectant EXOSC10 dans WB. Adapté pour Humain.

Aperçu rapide pour EXOSC10 anticorps (AA 586-885) (ABIN7267062)

Antigène: EXOSC10 (Exosome Component 10 (EXOSC10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EXOSC10 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-EXOSC10 anticorps

Épitope: AA 586-885

Fonction: EXOSC10 Rabbit pAb

Séquence: VAAGVKKSGP LPSAERLENV LFGPHDCSHA PPDGYPIIPT SGSVPVQKQA SLFPDEKEDN LLGTTCLIAT AVITLFNEPS AEDSKKGPLT VAQKKAQNIM ESFENPFRMF LPSLGHRAPV SQAAKFDPST KIYEISNRWK LAQVQVQKDS KEAVKKKAAE QTAAREQAKE ACKAAAEQAI SVRQQVVLEN AAKKRERATS DPRTTEQKQE KKRLKISKKP KDPEPPEKEF TPYDYSQSDF KAFAGNSKSK VSSQFDPNKQ TPSGKKCIAA KKIKQSVGNK SMSFPTGKSD RGFRYNWPQR

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 586-885 of human EXOSC10 (NP_001001998.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur EXOSC10

Antigène: EXOSC10 (Exosome Component 10 (EXOSC10))

Autre désignation: EXOSC10

Sujet: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR and/or Ig variable region somatic hypermutation (SHM by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA.,EXOSC10,PM-Scl,PM/Scl-100,PMSCL,PMSCL2,RRP6,Rrp6p,p2,p3,p4,Epigenetics & Nuclear Signaling,RNA Binding,Immunology & Inflammation,EXOSC10

Poids moléculaire: 98kDa/100kDa

ID gène: 5394

UniProt: Q01780