TNNT3 anticorps (AA 147-256)

N° du produit ABIN7267145

L’anticorps anti-TNNT3 Polyclonal Lapin est utilisé pour la détection de TNNT3 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour TNNT3 anticorps (AA 147-256) (ABIN7267145)

Antigène: TNNT3 (Fast Skeletal Troponin T (TNNT3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNNT3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TNNT3 anticorps

Épitope: AA 147-256

Fonction: TNNT3 Rabbit pAb

Séquence: SMGANYSSYL AKADQKRGKK QTAREMKKKI LAERRKPLNI DHLGEDKLRD KAKELWETLH QLEIDKFEFG EKLKRQKYDI TTLRSRIDQA QKHSKKAGTP AKGKVGGRWK

Réactivité croisée: Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 147-256 of human TNNT3 (NP_001036246.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TNNT3

Antigène: TNNT3 (Fast Skeletal Troponin T (TNNT3))

Autre désignation: TNNT3

Sujet: The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein, also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B).,TNNT3,TNTF,troponin T3,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,TNNT3

Poids moléculaire: 29kDa/30kDa/31kDa

ID gène: 7140

UniProt: P45378