Glutathione Peroxidase 2 anticorps (AA 100-180)

N° du produit ABIN7267435

Cet anticorps Lapin Polyclonal détecte spécifiquement Glutathione Peroxidase 2 dans WB et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour Glutathione Peroxidase 2 anticorps (AA 100-180) (ABIN7267435)

Antigène: Glutathione Peroxidase 2 (GPX2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glutathione Peroxidase 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Glutathione Peroxidase 2 anticorps

Épitope: AA 100-180

Fonction: GPX2 Rabbit pAb

Séquence: TLVQKCEVNG QNEHPVFAYL KDKLPYPYDD PFSLMTDPKL IIWSPVRRSD VAWNFEKFLI GPEGEPFRRY SRTFPTINIE P

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 100-180 of human GPX2 (NP_002074.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Glutathione Peroxidase 2

Antigène: Glutathione Peroxidase 2 (GPX2)

Autre désignation: GPX2

Sujet: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.,GPX2;GI-GPx;GPRP;GPRP-2;GPx-2;GPx-GI;GSHPX-GI;GSHPx-2,Cell Biology & Developmental Biology,Endocrine & Metabolism,GPX2

Poids moléculaire: 21kDa

ID gène: 2877

UniProt: P18283

Pathways: Thyroid Hormone Synthesis