LAPTM4B anticorps (AA 218-317)

N° du produit ABIN7268341

Détail du produit anti-LAPTM4B anticorps

Antigène: LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))

Épitope: AA 218-317

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAPTM4B est non-conjugé

Application: Western Blotting (WB)

Fonction: LAPTM4B Rabbit pAb

Séquence: NSIQEYIRQL PPNFPYRDDV MSVNPTCLVL IILLFISIIL TFKGYLISCV WNCYRYINGR NSSDVLVYVT SNDTTVLLPP YDDATVNGAA KEPPPPYVSA

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 218-317 of human LAPTM4B (NP_060877.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur LAPTM4B

Antigène: LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))

Autre désignation: LAPTM4B (LAPTM4B Produits)

Synonymes: anticorps LAPTM4beta, anticorps LC27, anticorps C330023P13Rik, anticorps lysosomal protein transmembrane 4 beta, anticorps lysosomal-associated protein transmembrane 4B, anticorps LAPTM4B, anticorps Laptm4b

Sujet: Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter to the lysosome, promoting entry of leucine and other essential amino acid (EAA into the lysosome, stimulating activation of proton-transporting vacuolar (V-ATPase protein pump (V-ATPase and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.,LAPTM4B,LAPTM4beta,LC27,Cancer,Tumor biomarkers,LAPTM4B

Poids moléculaire: 25kDa/35kDa/41kDa

ID gène: 55353

UniProt: Q86VI4