MELK anticorps

N° du produit ABIN7268411

Détail du produit anti-MELK anticorps

Antigène: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MELK est non-conjugé

Application: Western Blotting (WB)

Fonction: MELK Rabbit mAb

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: A synthesized peptide derived from human MELK

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MELK

Antigène: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Autre désignation: MELK (MELK Produits)

Synonymes: anticorps MELK, anticorps xmelk, anticorps Melk, anticorps HPK38, anticorps AI327312, anticorps MPK38, anticorps mKIAA0175, anticorps fb71b01, anticorps fe01f04, anticorps wu:fb71b01, anticorps wu:fe01f04, anticorps maternal embryonic leucine zipper kinase, anticorps maternal embryonic leucine zipper kinase L homeolog, anticorps MELK, anticorps melk, anticorps cgd5_2270, anticorps Melk, anticorps melk.L

Sujet: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.,HPK38,Cell Biology & Developmental Biology,Cell Cycle,Embryonic Stem Cells,Kinase,Signal Transduction,Stem Cells,MELK

Poids moléculaire: 75kDa

ID gène: 9833

UniProt: Q14680