MTMR6 anticorps (AA 382-621)

N° du produit ABIN7268765

L’anticorps anti-MTMR6 Polyclonal Lapin est utilisé pour la détection de MTMR6 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour MTMR6 anticorps (AA 382-621) (ABIN7268765)

Antigène: MTMR6 (Myotubularin Related Protein 6 (MTMR6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTMR6 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MTMR6 anticorps

Épitope: AA 382-621

Fonction: MTMR6 Rabbit pAb

Séquence: RCGQLDGDPK EVSPVFTQFL ECVWHLTEQF PQAFEFSEAF LLQIHEHIHS CQFGNFLGNC QKEREELKLK EKTYSLWPFL LEDQKKYLNP LYSSESHRFT VLEPNTVSFN FKFWRNMYHQ FDRTLHPRQS VFNIIMNMNE QNKQLEKDIK DLESKIKQRK NKQTDGILTK ELLHSVHPES PNLKTSLCFK EQTLLPVNDA LRTIEGSSPA DNRYSEYAEE FSKSEPAVVS LEYGVARMTC

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 382-621 of human MTMR6 (NP_004676.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MTMR6

Antigène: MTMR6 (Myotubularin Related Protein 6 (MTMR6))

Autre désignation: MTMR6

Sujet: Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3P and phosphatidylinositol 3,5-bisphosphate (Probable. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5P2 but also to phosphatidylinositol 3-phosphate (PtdIns(3P, phosphatidylinositol 4-phosphate (PtdIns(4P, and phosphatidylinositol 5-phosphate (PtdIns(5P, phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport (By similarity. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+ T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels.,MTMR6,Signal Transduction,MTMR6

Poids moléculaire: 63kDa/71kDa

ID gène: 9107

UniProt: Q9Y217

Pathways: Inositol Metabolic Process