OMA1 anticorps (AA 360-524)

N° du produit ABIN7269095

L’anticorps Lapin Polyclonal anti-OMA1 a été validé pour WB et IF. Il convient pour détecter OMA1 dans des échantillons de Humain.

Aperçu rapide pour OMA1 anticorps (AA 360-524) (ABIN7269095)

Antigène: OMA1 (OMA1 Zinc Metallopeptidase Homolog (OMA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OMA1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-OMA1 anticorps

Épitope: AA 360-524

Fonction: OMA1 Rabbit pAb

Séquence: AICPRDSLAL LCQWIQSKLQ EYMFNRPYSR KLEAEADKIG LLLAAKACAD IRASSVFWQQ MEFVDSLHGQ PKMPEWLSTH PSHGNRVEYL DRLIPQALKI REMCNCPPLS NPDPRLLFKL STKHFLEESE KEDLNITKKQ KMDTLPIQKQ EQIPLTYIVE KRTGS

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 360-524 of human OMA1 (NP_660286.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur OMA1

Antigène: OMA1 (OMA1 Zinc Metallopeptidase Homolog (OMA1))

Autre désignation: OMA1

Sujet: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae. In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome. May also cleave UQCC3 in response to mitochondrial depolarization. Also acts as an activator of the integrated stress response (ISR: in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1, which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity. Binds cardiolipin, possibly regulating its protein turnover (By similarity. Required for the stability of the respiratory supercomplexes (By similarity.,OMA1,2010001O09Rik,DAB1,MPRP-1,MPRP1,YKR087C,ZMPOMA1,peptidase,Cell Biology & Developmental Biology,Ubiquitin,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,OMA1

Poids moléculaire: 60kDa/55kDa

ID gène: 115209

UniProt: Q96E52