PYM anticorps

N° du produit ABIN7269181

Cet anticorps Lapin Polyclonal détecte spécifiquement PYM dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour PYM anticorps (ABIN7269181)

Antigène: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PYM est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-PYM anticorps

Fonction: PYM1 Rabbit pAb

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant protein of human PYM1.

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PYM

Antigène: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Autre désignation: PYM1

Sujet: Key regulator of the exon junction complex (EJC, a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA, the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.,PYM, WIBG,Epigenetics & Nuclear Signaling,PYM1

ID gène: 84305

UniProt: Q9BRP8